Package: mbbe 0.1.0

Mark Sale

mbbe: Model Based Bio-Equivalence

Uses several Nonlinear Mixed effect (NONMEM) models (as NONMEM control files) to perform bootstrap model averaging and Monte Carlo Simulation for Model Based Bio-Equivalence (MBBE). Power is returned as the fraction of the simulations with successful bioequivalence (BE) test, for maximum concentration (Cmax), Area under the curve to the last observed value (AUClast) and Area under the curve extrapolate to infinity (AUCinf). See Hooker, A. (2020) Improved bioequivalence assessment through model-informed and model-based strategies <https://www.fda.gov/media/138035/download>.

Authors:Mark Sale [aut, cre], James Craig [aut], Michael Tomashevskiy [aut]

mbbe_0.1.0.tar.gz
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mbbe.pdf |mbbe.html✨
mbbe/json (API)

Peer review:

Bug tracker:https://github.com/certara/mbbe/issues

On CRAN:

5 exports 1.59 score 55 dependencies 3 scripts 168 downloads

Last updated 8 months agofrom:11334b7c78. Checks:OK: 7. Indexed: yes.

Exports:calc_NCAcalc_powerrun_examplerun_mbberun_mbbe_json

Dependencies:backportscheckmateclicodetoolscolorspacecpp11digestdplyremmeansestimabilityfansifarverfurrrfuturegenericsggplot2globalsgluegtableisobandjsonlitelabelinglatticelifecyclelistenvmagrittrMASSMatrixmgcvmunsellmvtnormnlmenumDerivparallellypillarpkgconfigPKNCAprocessxpspurrrR6RColorBrewerrlangscalesstringistringrtibbletictoctidyrtidyselectutf8vctrsviridisLitewithrxml2