Package: mbbe 0.1.0

Mark Sale

mbbe: Model Based Bio-Equivalence

Uses several Nonlinear Mixed effect (NONMEM) models (as NONMEM control files) to perform bootstrap model averaging and Monte Carlo Simulation for Model Based Bio-Equivalence (MBBE). Power is returned as the fraction of the simulations with successful bioequivalence (BE) test, for maximum concentration (Cmax), Area under the curve to the last observed value (AUClast) and Area under the curve extrapolate to infinity (AUCinf). See Hooker, A. (2020) Improved bioequivalence assessment through model-informed and model-based strategies <https://www.fda.gov/media/138035/download>.

Authors:Mark Sale [aut, cre], James Craig [aut], Michael Tomashevskiy [aut]

mbbe_0.1.0.tar.gz
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mbbe_0.1.0.tgz(r-4.5-any)mbbe_0.1.0.tgz(r-4.4-any)mbbe_0.1.0.tgz(r-4.3-any)
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mbbe.pdf |mbbe.html✨
mbbe/json (API)

# Install 'mbbe' in R:
install.packages('mbbe', repos = c('https://certara.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/certara/mbbe/issues

On CRAN:

Conda-Forge:

4.30 score 3 scripts 196 downloads 5 exports 55 dependencies

Last updated 1 years agofrom:11334b7c78. Checks:8 OK. Indexed: yes.

TargetResultLatest binary
Doc / VignettesOKFeb 09 2025
R-4.5-winOKFeb 09 2025
R-4.5-macOKFeb 09 2025
R-4.5-linuxOKFeb 09 2025
R-4.4-winOKFeb 09 2025
R-4.4-macOKFeb 09 2025
R-4.3-winOKFeb 09 2025
R-4.3-macOKFeb 09 2025

Exports:calc_NCAcalc_powerrun_examplerun_mbberun_mbbe_json

Dependencies:backportscheckmateclicodetoolscolorspacecpp11digestdplyremmeansestimabilityfansifarverfurrrfuturegenericsggplot2globalsgluegtableisobandjsonlitelabelinglatticelifecyclelistenvmagrittrMASSMatrixmgcvmunsellmvtnormnlmenumDerivparallellypillarpkgconfigPKNCAprocessxpspurrrR6RColorBrewerrlangscalesstringistringrtibbletictoctidyrtidyselectutf8vctrsviridisLitewithrxml2

Introduction

Rendered fromIntroduction.Rmdusingknitr::rmarkdownon Feb 09 2025.

Last update: 2024-02-01
Started: 2023-05-24

Step-by-Step

Rendered fromStep-by-Step.Rmdusingknitr::rmarkdownon Feb 09 2025.

Last update: 2024-01-17
Started: 2023-07-26